Статины и полиненасыщенные жирные кислоты

Одной из причин развития атеросклероза является дефицит эссенциальных (не синтезирующихся в организме) полиненасыщенных жирных кислот. Дефицит этих жирных кислот может обуславливаться:

1 Недостатком в пище

2 Нарушениями всасывания в кишечнике и транспорта в организме.

Одной из составляющих самой высокой в мире средней продолжительности жизни японцев (85,6 лет) является повышенное употребление с пищей полиненасыщенных жирных кислот в составе морепродуктов. Эссенциальные жирные кислоты переносятся в организме в начале в составе лецитина (фосфатидилхолина) являющегося основным фосфолипидом формирующим ЛПВП, а затем в составе эфиров холестерола с использованием белков переносящих эфиры холестерола (ЭХПБ)  в состав ЛПНП. В свою очередь ЛПНП захватываются специфическими рецепторами периферических клеток и, таким образом, доставляют необходимые для их жизнедеятельности жирные кислоты. Исходя из данного механизма транспорта жирных кислот можно заключить, что холестерол необходим для переноса эссенциальных жирных кислот. Снижение активности продукции холестерола в организме способно вызвать дефицит этих жирных кислот в клетках и, как следствие, нарушить их жизнедеятельность. Современные гиполипидемические препараты статины угнетают (ингибируют) активность ключевого фермента синтеза холестерола – ОМГ- редуктазы и, таким образом, снижают активность синтеза холестерола в организме. Следствием этого воздействия может быть нарушение транспорта эссенциальных жирных кислот и их дефицит в клетках. Подтверждение такого сценария можно найти в работе Японских ученых исследовавших влияние статинов на содержание полиненасыщенных жирных кислот у больных ишемической болезнью сердца. В работе сделан вывод о снижении статинами содержания эссенциальных жирных кислот. Таким образом данный механизм и проведенные исследования показывают необходимость жесткого лабораторного контроля применения статинов в практической кардиологии.

Опубликовано 13 Авг 2012 в 21:25. Рубрика: Зачем нужен холестерол.
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